Indiana CTSI Receives $33M NIH Grant to Improve Health Statewide, with Public’s Participation

Andrea Zeek

Indiana consistently lands near the bottom of the nation’s health ranking lists, with too many babies dying before their first birthday and too many people smoking and abusing drugs.

Indiana Ctsi Logo 768x267The Indiana CTSI is a statewide research partnership among Indiana University, Purdue University and the University of Notre Dame, represented by the institute’s three-color logo.

A statewide network of researchers and staff at Indiana University, Purdue University and the University of Notre Dame have been working together to reverse this poor state of health, and are now seeking the help of Indiana residents of all ages and backgrounds as their partners.

Indiana’s preeminent research universities are collaborating through the Indiana Clinical and Translational Sciences Institute (CTSI), which has recently been awarded more than $33 million in renewed National Institutes of Health (NIH) funding for the next five years. The institute was founded in 2008 by Anantha Shekhar, MD, PhD, Indiana CTSI director and IU associate vice president of research and University Clinical Affairs.

“We are thrilled to receive this continued support from the NIH,” said Dr. Shekhar, who is also executive associate dean for research affairs at IU School of Medicine. “It enables us to continue improving health for people living in Indiana, to recruit more researchers and seed innovations in the state, and to speed the movement of discoveries across the universities’ labs to solutions benefiting people living in Indiana.”

Carmel Egan, PhD, Indiana CTSI chief operating officer, said the story of the institute reads like a great novel.

“The Indiana CTSI was founded in 2008 to improve health and the economy of Indiana and beyond through building translational research programs,” Dr. Egan said. “The institute used its first multimillion dollar award from the NIH to build research infrastructure, recruit talent and identify the state’s greatest health challenges. The CTSI’s second grant award built bridges and collaborations and initiated research projects. Now, we are seeing the outcomes of that effort and improvements in health are being made, with more to come.”

Some of the progress researchers have made through the Indiana CTSI in recent years includes alerting state and local lawmakers to dangerous lead levels in South Bend and creating lead test kits as the first line of prevention against lead exposure. Researchers are also reducing risk factors for infant mortality in Central Indiana by lowering rates of depression and anxiety by 20 percent and improving nutrition intake, with a reported 24 percent fewer meals skipped per week.

“There is no better time than now to be living in Indiana from a health perspective,” Dr. Shekhar said. “Our vision is of an Indiana that is one of the nation’s healthiest states, and in order to achieve that goal, we need community participation in all phases of research—from the basic science that happens in the laboratory to the clinical care provided to patients—to help shed new light on the best ways to prevent, treat and manage health issues in our state.”

The Indiana CTSI has also launched a new initiative called “All IN for Health,” which aims to sign up at least 100,000 Indiana residents to its health research volunteer registry over the next three years. So far, the initiative has recruited more than 6,000 people.

The All IN for Health website,, provides valuable resources aligned with the major health issues affecting Indiana, such as information for expectant mothers interested in quitting smoking. The website also offers opportunities to become research volunteers and be matched to any of the 1,000 active Indiana-based research studies made possible through IU, Purdue and Notre Dame. 

The grant numbers are UL1TR002529, KL2TR002530 and TL1TR002531.

About the Indiana Clinical and Translational Sciences Institute

The Indiana CTSI brings together the state’s brightest minds to solve Indiana’s most pressing health challenges through research. It is a statewide partnership among Indiana University, Purdue University, the University of Notre Dame and numerous life sciences businesses, government entities and community organizations. The Indiana CTSI engages with the public at every level of research—from basic science to patient care. It has been continuously funded by multimillion dollar grants from the National Institutes of Health since the Indiana CTSI’s founding in 2008 and is housed at the Indiana University School of Medicine. For more information, visit

Originally published by Andrea Zeek at on May 22, 2018.

Originally published by Andrea Zeek at on May 22, 2018.