Challenges in the discovery of Gram-negative antibacterials: the entry & efflux problem

February 6-7, 2017

5601 Fishers Lane, Rockville, MD

Successful antibiotic discovery is challenging, in large part, due to the difficulty in finding and designing molecules that get into and stay inside of Gram-negative bacteria. The ability to measure compound entry, accumulation, and efflux avoidance in Gram-negative bacteria is important to establish physicochemical guidelines for more rational drug design and optimization.

NIAID is co-hosting the “Challenges in the discovery of Gram-negative antibacterials: the entry & efflux problem” workshop with The Pew Charitable Trusts to identify concrete next steps and collaboration opportunities to better find and design molecules that get into and stay inside of Gram-negative bacteria.

Meeting space is limited but the workshop will be webcast via webinar. To register for the webinar, please visit

https://respond.niaid.nih.gov/conferences/Gram_neg_antibacterials2017/Pages/default.aspx

Questions about the workshop can be sent to Dr. Jane Knisely , Bacteriology and Mycology Branch, DMID/ NIAID.